Penicillins of a wide spectrum of action. Ampicillin. Instructions

Embedded in a box with the drug ampicillinthe manual is unlikely to tell the history of the appearance of this drug and its benefits. In modern pharmacology, they combined into a group of beta-lactam antibiotics (betalactams) and cephalosporins, and penicillins. The drugs included in this group are the most effective in modern antibiotic therapy. Their bactericidal action and high activity in relation, mainly to gram-positive bacteria, the ability to quickly provide antibacterial effect and the predominant effect on bacteria in the proliferation stage, was highly appreciated by the medical profession of the whole world. Betalactams also have an amazing ability to penetrate the cell and already inside to amaze the pathogens located there. The effectiveness of the treatment process is enhanced by the fact that microorganisms are not able to quickly develop resistance to them. In addition, Betalaktam antibiotics have relatively low toxicity, they are well tolerated even with prolonged use in large doses.

The group of penicillins combines drugs withhigh chemotherapeutic efficacy and selectivity of antimicrobial effects. To date, these drugs can rightfully be called ideal medicines. According to its antimicrobial effect, penicillins are equated with physiologically active substances on which the immune functions of the body are entrusted, lysozyme can serve as an example of such a substance.

Despite the positive properties of penicillins,pharmacologists for a long time worried a number of their shortcomings. These include the possibility of sensitization - an increased likelihood of developing allergic reactions. It also reduced the effectiveness of medications, rapid elimination of penicillins from the body and the effectiveness of the action only in the period when the division of the microbial cell. Coping with these and many other shortcomings was helped by the creation of semisynthetic penicillins.

In this group of penicillins, having propertiesa broad-spectrum drug, ampicillin is included. Instruction among the indications for the use of this drug is the treatment of pyelitis, salmonellosis, pneumonia, glomerulonephritis, bronchitis, sinusitis and a number of other diseases.

Medical practice involves the use ofmedicinal product in such forms: ampicillin trihydrate, ampicillin sodium salt and ampicillin directly. The instruction clearly indicates that the order of taking and dosage for each specific case of infection is prescribed by the doctor. Experiment with this medicine is impossible. In addition, the doctor chooses the most acceptable way of taking ampicillin. Injections are prescribed in rare cases. Usually this is a reception inside.

According to the form of release - it is 0.25 gram capsules orpills. You can also take ampicillin powder. Suspension according to the dosage is calculated depending on the doctor's prescribed disposable intake of the active substance.

Externally ampicillin is afine crystalline white powder. It tastes bitter. It dissolves poorly in water, practically does not dissolve either in chloroform, in ethanol, or in ether. Ampicillin sodium salt can be in the form of a powder or a porous mass of white or a creamy hue. Easily soluble in water, in alcohol. It shows the properties of hygroscopicity. Ampicillin trihydrate is a crystalline powder of white color. In water it dissolves, in ethanol it practically is insoluble.

Do not recommend the use of ampicillin instructions incases of hypersensitivity to penicillins, infectious mononucleosis, liver failure, lymphocytic leukemia, children up to one month. Possible contraindications for gastrointestinal diseases.